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Home > Recipes > Whiskey

Penicillin Cocktail

The penicillin cocktail is a scotch-based modern classic, originating at the now-shuttered NYC cocktail bar, Milk and Honey. It's a sophisticated whiskey cocktail with the immunity-boosting flavors of honey and ginger; hence, its medicinal name. But, even if you aren't under the weather, this cocktail will get you through a tough day.
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Overhead photo of a penicillin cocktail, garnished with a lemon peel rosette on a metal cocktail skewer.

Why we love the penicillin cocktail

I’ve been fighting off a cold for the last few days, and it got me thinking about how much a drink – warm or cold, spiked or not – can really make you feel better. There are some drinks that just get your through those days.

For me, I love a hot tea or a strong cocktail. This one packs a punch. Think Starbucks medicine ball, but with booze.

The honey ginger syrup is full of flavor – a little spicy and a little sweet – but it balances so well with the smoky scotch.

More modern classics: piña verde / naked and famous / hugo spritz / blood and sand cocktail / orange crush cocktail

A penicillin cocktail on a colorful coaster, garnished with a lemon peel rosette.
Close up of a cocktail garnished with a lemon peel rosette.

Ingredients & Substitutions

  • Blended scotch whiskey – This is the base of your cocktail.
  • Honey ginger simple syrup – Honey ginger syrup gives this cocktail it’s signature flavor. It’s super easy to make.
  • Lemon juice – This drink is really simple, so you want to use fresh squeezed lemon juice for the best flavor.
  • Single malt scotch whiskey – This adds an element of complexity to the cocktail. A little bit goes a long way, and if you have it, I recommend using something a little higher end and a little smoky.

Making changes to a recipe can result in recipe failure. Any substitutions listed below are simple changes that I believe will work in this recipe, but results are not guaranteed.

A penicillin cocktail garnished with a lemon peel rose.

How to make this penicillin cocktail recipe

Mix the cocktail. Fill a cocktail shaker with ice and add the ingredients. Cover and shake until cold. This should take about 20 seconds or so.

Garnish and serve. Strain into a cocktail glass filled with large ice and garnish with a lemon peel. Express the peel over the cocktail first, but then after that you can make it pretty. I spun mine into a little rose and put it on a cocktail pick.

More whiskey cocktails: cranberry orange whiskey sour / apple cider bourbon cocktail / lion’s tail cocktail / salted maple old fashioned

A scotch whiskey drink, garnished with a lemon peel rose.

Penicillin Cocktail

By: Melissa Belanger
The penicillin cocktail is a scotch-based modern classic, originating at the now-shuttered NYC cocktail bar, Milk and Honey. It's a sophisticated whiskey cocktail with the immunity-boosting flavors of honey and ginger; hence, its medicinal name. But, even if you aren't under the weather, this cocktail will get you through a tough day.
Prep Time: 2 minutes mins
1
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Ingredients 

  • 2 ounces blended scotch
  • 3/4 ounce lemon juice
  • 3/4 honey ginger syrup
  • 1/4 ounce single malt scotch
  • For garnish: lemon peel

Instructions 

  • Fill a cocktail shaker with ice and add cocktail ingredients. Cover and shake until cold.
  • Strain into a cocktail glass with large ice and garnish with a lemon peel.
Last step!Share a picture on Instagram and tag me at @anothercocktailblog!

Nutrition Information

Calories: 166kcal (8%), Carbohydrates: 2g (1%), Protein: 0.1g, Fat: 0.1g, Saturated Fat: 0.01g, Sodium: 1mg, Potassium: 23mg (1%), Fiber: 0.1g, Sugar: 1g (1%), Vitamin A: 1IU, Vitamin C: 8mg (10%), Calcium: 1mg, Iron: 0.1mg (1%)

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Hi! I’m Melissa.

I’m so happy you’re here!

I’m a food blogger, photographer and cocktail enthusiast – and a mom of 2. I started Another Cocktail Blog to share the fun of mixing cocktails at home, so grab some ice and stay for a while.

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